Rh Ew antigen in a multi-transfused patient with sickle cell disease
نویسندگان
چکیده
منابع مشابه
Hemoglobin-specific antibody in a multiply transfused patient with sickle cell disease.
Human hemoglobins (Hbs) are known to be immunogenic, and both normal and variant forms of Hb have been shown to stimulate antibody formation in a variety of animal species. In patients who are homozygous for the sickle Hb (HbS) mutation, transfusion of normal, HbA-containing erythrocytes provides a potential stimulus for HbA alloimmunization. We tested serum samples for the presence of anti-Hb ...
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enal manifestations in sickle cell disease (SCD) occur in onehird of adolescents and young adults.1 These manifestations ccur because the kidney is sensitive to hypoxia-induced vasocclusion resulting from the adhesion of sickled red blood cells o the endothelium.2,3 The renal medulla is characterized by cidosis, hypertension, and hypoxia. These factors promote he polymerization and sickling of ...
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ژورنال
عنوان ژورنال: Hematology, Transfusion and Cell Therapy
سال: 2018
ISSN: 2531-1379
DOI: 10.1016/j.htct.2018.02.007